Tri-Heart Plus vs Simparica Trio

It’s easy to keep your dog and your family healthy when you choose the parasite preventative that meets your pup’s specific needs. A couple of the best-loved choices are Tri-Heart Plus and Simparica Trio. Both of these products are safe and effective, but they are also unique in many ways. Check out the table and information below to find out which medication is best for your pet and your family!

Tri-Heart Plus for Dogs

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Save $5 off $50
with coupon code COMPARE5

How do Tri-Heart Plus and Simparica Trio differ?

First, we’ll discuss the parallels between these two incredible formulas. One key feature that these products have in common is that they both protect your dog against heartworms, hookworms, and roundworms. They are also both beef-flavored, once-monthly, chewable tablets, and they both require a prescription from a veterinarian.

Now, let’s talk about the many differences between these formulas. Tri-Heart Plus uses a combination of two active ingredients - Ivermectin and Pyrantel Pamoate - to protect your dog against harmful parasites. It is safe for use in puppies ages 6 weeks and older, as well as pregnant and breeding dogs.

Simparica Trio combines Saroloner, Pyrantel, and Moxidectin to protect against parasites. It offers added protection against fleas, flea eggs, and flea larvae, and it also kills ticks. This product has not been proven safe for use in pregnant, lactating, or breeding dogs, and it is safe for use in puppies weighing at least 2.8 pounds with a minimum age of 8 weeks.

How can I choose between Tri-Heart Plus and Simparica Trio?

Now that you’re aware of the similarities and differences between these products, it’s time to decide which one is best for your individual dog. If you have a puppy between the ages of 6 and 8 weeks, a puppy that weighs less than 2.8 pounds, or a breeding, lactating, or pregnant dog, the safest option is Tri-Heart Plus. If your dog isn’t already taking a flea and tick treatment and you love the idea of a convenient, broad-spectrum parasite preventative, Simparica Trio might be a great option for your pet. If you’re still undecided, your decision might simply come down to your own personal preferences.

With this wealth of information in mind, it’s a good idea to make an appointment with your veterinarian to start a discussion and get a prescription for your pet’s medication. Your vet can address any concerns you might have and help you make a final decision on which product is best for your pup. Then, head to GiantEaglePetRx to get the best price on your pet’s prescription! If you find yourself with any questions or worries, be sure to reach out to the GiantEaglePetRx pharmacists for a pet parent consultation.

Feature Tri-Heart Plus Simparica Trio
Kills Fleas No Yes
Repels Fleas No No
Kills Flea Eggs and Larvae No Yes
Kills Ticks No Yes
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes Yes
Other Parasites Hookworms and Roundworms Hookworms and Roundworms
Waterproof Yes since taken orally Yes
How Long to work N/A N/A
Taste Beef Flavored Beef Flavored
Active Ingredient Ivermectin and Pyrantel Pamoate Sarolaner, moxidectin, and pyrantel
RX Required Yes Yes
Application Type Chewable Tablet Chewable Tablet
Dosing 1 tablet per month 1 tablet per month
Age Dogs 6 weeks and older Dogs 8 weeks and 2.8lbs or more
Manufacturer Merck Animal Health Boehringer Ingelheim
Safety Safe for pregnant or breeding females. has not been evaluated in breeding, pregnant, or lactating dogs.