Tri-Heart Plus vs Sentinel

Choosing a heartworm and parasite preventative is one of the most important jobs you have as a dog parent. Two of the most popular medications are Tri-Heart Plus and Sentinel. Each of these formulas boasts a number of advantages. We’ve put together a table and some additional information to help you select the best product for your specific pet and his or her needs.

Tri-Heart Plus for Dogs

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Save $5 off $50
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Save $5 off $50
with coupon code COMPARE5

What are the differences between Tri-Heart Plus and Sentinel?

One key difference between two products is that they contain different active ingredients. Tri-Heart Plus contains Pyrantel Pamoate and Ivermectin, while Sentinel combines Milbemycin Oxime with Lufenuron. Both formulas protect against heartworms, roundworms, and hookworms. However, Sentinel offers added protection against whipworms, and it also ends the flea life cycle by inhibiting the development of flea larvae and eggs.

Both of these once-monthly medications come in the form of a convenient, chewable tablet. They are only available with a prescription from your veterinarian. They are also both safe for use in pregnant or breeding dogs, along with puppies. Tri-Heart Plus can be given to puppies ages 6 weeks and up, and Sentinel is safe for use in puppies from the age of 4 weeks. Sentinel is also safe for use in lactating females.

Choosing between Tri-Heart Plus and Sentinel

If you’re searching for an effective and safe way to protect your dog against heartworms, hookworms, and roundworms, you can’t go wrong with either of these incredible products. If you have a pregnant or breeding dog or a puppy over the age of 6 weeks, you might still be unsure about which product is best for your dog. If you have a puppy between 4 and 6 weeks old, you have a lactating dog, or you want to protect your dog against whipworms, you might want to discuss Sentinel with your vet. It’s important to talk to your veterinarian to discuss your options further and get a prescription.

With your dog’s prescription in hand, it’s time to come to GiantEaglePetRx and order your dog’s medications for the lowest price you’ll find anywhere! If you have any lingering concerns or questions, contact the GiantEaglePetRx pharmacists for a free pet parent consultation.

Feature Tri-Heart Plus Sentinel
Kills Fleas No No
Repels Fleas No No
Kills Flea Eggs and Larvae No Stops development
Kills Ticks No No
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes Yes
Other Parasites Hookworms and Roundworms Roundworms, Whipworms, and Hookworms
Waterproof Yes since taken orally Yes
How Long to work N/A Breaks cycle of fleas and eggs. Does not kill existing flea infestation
Taste Beef Flavored Savory Beef
Active Ingredient Ivermectin and Pyrantel Pamoate Milbemycin Oxime and Lufenuron
RX Required Yes Yes
Application Type Chewable Tablet Chewable Tablet
Dosing 1 tablet per month 1 tablet per month
Age Dogs ages 6 weeks and older Dogs 4 weeks and older
Manufacturer Merck Animal Health Merck Animal Health
Safety Safe for pregnant or breeding females. Breeding, pregnant, and lactating dogs may use.