Simparica Trio vs Advantage Multi

Controlling and preventing dangerous and bothersome pests is an essential part of keeping your pup happy and healthy. Two of the best-loved options for parasite and heartworm prevention are Simparica Trio and Advantage Multi. Each product works in a different way to protect your dog, and they each feature unique advantages that can help you choose between them. See below for a table and some information that compares these two effective formulas.

Simparica Trio

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Advantage Multi

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What makes Simparica Trio different from Advantage Multi?

These two medications share some similarities. Both products offer protection against roundworms, hookworms, fleas, and heartworms. They are both once-monthly, prescription-only treatments, and they are both safe for use in puppies. Simparica Trio is safe for puppies over 2.8 pounds and 8 weeks of age, while Advantage Multi can be given to puppies over 3 pounds and 7 weeks old. Neither product is proven safe for use in pregnant, lactating, or breeding dogs, so be sure to consult your veterinarian if this describes your dog.

Simparica Trio contains three active ingredients - Pyrantel, Moxidectin, and Saroloner. These chewable, beef-flavored tablets also work to kill ticks, flea larvae, and flea eggs. Advantage Multi uses Imidacloprid and Moxidectin to provide added protection against ear mites. This formula is a topical treatment.

The products discussed here are formulated for dogs only. However, Advantage Multi for Cats is an incredible, broad-spectrum option that’s safe for use in your feline friend.

Closing thoughts on Simparica Trio vs. Advantage Multi

Your decision between these products might be as simple as personal preference - do you like giving your dog oral medications like Simparica Trio, or are topical treatments like Advantage Multi more your speed? If you have a puppy between 7 and 8 weeks of age, Advantage Multi is the safest choice. If you’re searching for ear mite protection, Advantage Multi might be the best option for your pup. If ticks, flea larvae, and flea eggs are your focus, Simparica Trio is a great way to protect your dog against these parasites.

Talk to your veterinarian about these and any other parasite preventatives you’re considering for your dog. Be sure to mention any concerns you might have during your dog’s appointment. If you find yourself with any other questions after returning home from the vet’s office, reach out to the GiantEaglePetRx pharmacists for a free pet parent consultation!

Feature Simparica Trio Advantage Multi
Kills Fleas Yes Yes
Repels Fleas No No
Kills Flea Eggs and Larvae Yes No
Kills Ticks Yes No
Repels Ticks No No
Repels Mosquitoes No No
Prevents Heartworm Yes Yes
Other Parasites Hookworms and Roundworms Ear mites, Roundworms, and Hookworms
Waterproof Yes Yes
How Long to work N/A Begins to kill fleas within 12 hours
Taste Beef Flavored N/A
Active Ingredient Sarolaner, Moxidectin, and Pyrantel Imidacloprid and Moxidectin
RX Required Yes Yes
Application Type Chewable Tablet Topical
Dosing 1 tablet per month 1 application per month
Age Dogs 8 weeks and 2.8lbs or more Dogs 7 weeks and older that weight at least 3 pounds
Manufacturer Boehringer Ingelheim Bayer Animal Health
Safety has not been evaluated in breeding, pregnant, or lactating dogs. Speak to your vet about risks associated with breeding, pregnant, or lactating dogs

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